Defocused Image Changes Signaling of Ganglion Cells in the Mouse Retina

ON direction-selective ganglion cells in the mouse retina.

Two types of ganglion cells (RGCs) compute motion direction in the retina: the ON-OFF direction-selective ganglion cells (DSGCs) and the ON DSGCs. The ON DSGCs are much less studied mostly due to the low encounter rate. In this study, we investigated the physiology, dendritic morphology and synaptic inputs of the ON DSGCs in the mouse retina. When a visual stimulus moved back and forth in the p...

Displaced ganglion cells in the rabbit retina.

Displaced ganglion cells were studied in the rabbit retina after filling them with horseradish peroxidase via injections into the optic nerve. These cells are primarily in areas outside of the visual streak. They are larger than other inner nuclear layer cells and are the size of the smallest neurons in the ganglion cell layer. Large labeled cells (greater than 20 microns) are found only in the...

Direction-Selective Ganglion Cells in the Retina

Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.

Sonic Hedgehog (Shh) signaling is an important determinant of vertebrate retinal ganglion cell (RGC) development. In mice, there are two major RGC populations: (1) the Islet2-expressing contralateral projecting (c)RGCs, which both produce and respond to Shh; and (2) the Zic2-expressing ipsilateral projecting RGCs (iRGCs), which lack Shh expression. In contrast to cRGCs, iRGCs, which are generat...

Survey on amacrine cells coupling to retrograde-identified ganglion cells in the mouse retina.

PURPOSE Retinal amacrine cells (ACs) may make inhibitory chemical synapses and potentially excitatory gap junctions on ganglion cells (GCs). The total number and subtypes of ACs coupled to the entire GC population were investigated in wild-type and three lines of transgenic mice. METHODS GCs and GC-coupled ACs were identified by the previously established LY-NB (Lucifer yellow-Neurobiotin) re...